Confirmed teams
The team news is in and there’s plenty of experimentation by England boss Thomas Tuchel.
Tuchel has handed full senior debuts to both James Trafford and James Garner with Tottenham Hotspur striker Dominic Solanke leading the line.
Meanwhile, Manchester United defender Harry Maguire comes back in and Jordan Henderson captains the side in the absence of Harry Kane.
A total of 11 changes have been made from England’s last fixture which saw them claim a 2-0 win over Albania in World Cup qualifying back in November.
England: Trafford, Livramento, Tomori, Maguire, Spence, Henderson, Garner, Foden, Madueke, Solanke, Rashford
Subs: Pickford, Hall, Wharton, Stones, Palmer, White, Ramsdale, Mainoo, Calvert-Lewin, Barnes, Bowen, Steele
Uruguay: Muslera, Varela, R. Araujo, Olivera, Piquerez, Valverde, Ugarte, De Arrascaeta, Canobbio, Aguirre, M. Araujo
Subs: Caceres, Fonseca, Gimenez, Martinez, Mele, Nunez, Pellistri, Rochet, J. Rodriguez, B. Rodriguez, Sanabria, Torres, Vina, Vinas, De la Cruz
